Tuesday, June 17, 2008

Lipotoxicity

Here's the new lipocentric news! What is not news, of course, is how lipocentric we're all getting, our fat or lipid-filled midriffs featured front and center in a pregnant abdomen sort of way. Researchers now, however, are theorizing that the fat load we carry as a result of overeating and undermoving is the primary metabolic driver behind the current epidemic of type 2 diabetes. Dr. Roger Unger of the Touchstone Center for Diabetes Research concludes in a recent JAMA editorial that "If this is in fact the case, [high blood sugar] should be corrected by eliminating the lipid overload."(1)

Want the skinny on fat overload? Check out: Lipotoxicity for the details.
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(1) Unger, RH. Reinventing Type 2 Diabetes. JAMA, March 12, 2008, Vol 299, No 10.

5 comments:

JeanMac said...

Sigh -

Ruth said...

I was counting the number of type 2 diabetics on our rehab unit today...about 2/3rds of the patients. Makes you think. How many strokes, amputations, neuropathies leading to falls, renal failures could have been avoided?

Wendy said...

Egads Judy - how do you manage 3 blogs! I'm having a hard time managing 1!!!
So that's why I'm starting to look pregnant. Yuk! All that fat stored everywhere (and I never used to have a midriff that bulged).
And throw a little (o.k. a lot) of stress into the mix......
I just hope all my bike rides this summer will pay off.

dorsey said...

I thought they figured this out years ago, long enough that even others (not as up on the news as you) had reported it. What am I missing? What's the surprising part here? Isn't this where all those gross diabetes hormones are produced?

Anonymous said...

In my family, my father and half my sibs were naturally lean, regardless of what they eat. And my mother and half my sibs were terribly overweight. Those with weight problems had health problems the others didn't have, including extreme high blood pressure and cholesterols, strokes, diabetes, allergies and Parkinson's. They all died at 75-80; the leans ones of unexpected heart attacks. I inherited the tendency to fat but decided very early to fight it and was successful, mostly because, I think, beginning in my early teens, I've loved my daily exercise routine and swimming. I was by many years the youngest of the sibs, so may or may not live longer than they did (all of them scoffed at exercise), but it doesn't matter. I enjoy excellent health still, and that's good enough.